Adaptation of Neisseria gonorrhoeae to the Female Reproductive Tract
نویسندگان
چکیده
منابع مشابه
The Pathobiology of Neisseria gonorrhoeae Lower Female Genital Tract Infection
Infection and disease associated with Neisseria gonorrhoeae, the gonococcus, continue to be a global health problem. Asymptomatic and subclinical gonococcal infections occur at a high frequency in females; thus, the true incidence of N. gonorrhoeae infections are presumed to be severely underestimated. Inherent to this asymptomatic/subclinical diseased state is the continued prevalence of this ...
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Epidemiological studies suggest H(2)O(2)-producing lactobacilli protect women against gonorrhea. Here we demonstrate that Lactobacillus crispatus and Lactobacillus jensenii, the most common lactobacilli in the female genital tract, inhibit gonococci in both acidic and neutral pH conditions. Inhibition was neutralized by bovine catalase, suggesting that H(2)O(2) is the primary mediator of inhibi...
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Historically, animal modeling of gonorrhea has been hampered by the exclusive adaptation of Neisseria gonorrhoeae to humans. Genital tract infection can be established in female mice that are treated with 17β-estradiol, however, and many features of experimental murine infection mimic human infection. Here we review the colonization kinetics and host response to experimental murine gonococcal i...
متن کاملOpacity proteins increase Neisseria gonorrhoeae fitness in the female genital tract due to a factor under ovarian control.
The neisserial opacity (Opa) proteins are a family of antigenically distinct outer membrane proteins that undergo phase-variable expression. Opa(+) variants of Neisseria gonorrhoeae strain FA1090 are selected in a cyclical pattern from the lower genital tract of estradiol-treated mice. Here we show that cyclical recovery of Opa(+) gonococci does not occur in ovariectomized mice; therefore, the ...
متن کاملEmbryology of the Female Reproductive Tract
2 Embryology of the Female Genitourinary Tract ................................................ 22 2.1 Development of the Gonads ..................................... 22 2.2 Relationship Between the Early Fetal Genital and Urinary Systems ................................................. 25 2.3 Development of the Fallopian Tubes Uterus, Cervix and Vagina............................................
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ژورنال
عنوان ژورنال: Microbiology Insights
سال: 2020
ISSN: 1178-6361,1178-6361
DOI: 10.1177/1178636120947077